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In particular lung function assessment and ophthalmological examination. When reviewing this article concerns were raised over the practicality of the above monitoring slit lamp biomicroscopy, visual acuity, fundoscopy) but more immediately or frequently if ECG and serum potassium levels (ideally every 6 -12 months).Lung function assessment (including 6 monthly chest X ray).Ophthalmological examination if there is pre-existing visual impairment.Lung function assessment (including chest X ray).Monitoring requirements Baseline assessments: Please liaise with the specialist who initiatedĪmiodarone to ensure that all patients on long term therapy are appropriately monitored for adverse reactions. The lead carer needs to beĬlearly identified for all patients requiring long term amiodarone treatment. The long half life of amiodarone (approximately 50ĭays) may contribute to a slow resolution of any adverse reactions once they are recognised. Hepatotoxicity, cardiac toxicity and both hyper and hypothyroidism. Neither was clear about who was doing the monitoring with the result that adverse reactions were only picked up when obviousĪmiodarone therapy is associated with a number of adverse reactions including pulmonary toxicity, visual disturbances, They found that patients were falling between primary or secondary care in terms of monitoring. One DHB reviewed all their patients on long term amiodarone therapy following publication of a Medsafe Prescriber Investigating the extent of the initial concern highlighted another safety issue for patients on long term amiodarone Because of the long half-life of amiodarone (15 to 142 days) and its active metabolite desethylamiodarone (14 to 75 days), adverse reactions and drug interactions can persist for several weeks following amiodarone discontinuation see Clinical Pharmacology (12.3). Who request a repeat prescription may have been discharged on a loading dose. In the meantime, please be aware that patients who have been initiated on amiodarone during a hospital admission and This problem is generated in secondary care and SQM is looking at how the accuracy of discharge summaries and their Approximately a quarter of the patients discharged on amiodarone are discharged on a loading dose.The possible extent of the problem was identified in two DHBs. The discharge summary does not make it clear that the patient is on a loading dose and that the dose should be reviewed.The discharge summary sent to general practice is often delayed so that the general practitioner is unaware that the.The problem: Some patients initiated on amiodarone in hospital are discharged on a loading dose and remain on this long